SCHEMBL28114649

SCHEMBL28114649

C=CCC(C#N)CCCCCC

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.41
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
FAAH O00519 1/20 0.34
DNM1 Q05193 2/20 0.33
ZDHHC20 Q5W0Z9 1/20 0.33
ZDHHC2 Q9UIJ5 1/20 0.33
ADH1B P00325 1/20 0.33
ADH1C P00326 1/20 0.33
ADH1A P07327 1/20 0.33
ADH4 P08319 1/20 0.33
ADH7 P40394 1/20 0.33
FFAR4 Q5NUL3 2/20 0.32
FFAR1 O14842 2/20 0.32
OPRM1 P35372 1/20 0.32
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5879379 0.98 TSHR (0.38) TSHRALDH1A1LMNAFAAHDNM1
SCHEMBL11070712 0.92 TSHR (0.37) TSHRALDH1A1DNM1
SCHEMBL6687143 0.85
SCHEMBL7047578 0.82 TSHR (0.40) TSHRALDH1A1LMNAFAAHZDHHC20
SCHEMBL4354554 0.82 TSHR (0.61) TSHRALDH1A1
SCHEMBL11051344 0.82 TSHR (0.40) TSHRALDH1A1LMNAFAAHZDHHC20
SCHEMBL31590958 0.82 TSHR (0.61) TSHRALDH1A1
SCHEMBL23530156 0.82
SCHEMBL985792 0.80 TSHR (0.46) TSHRLMNADNM1ZDHHC20ZDHHC2
SCHEMBL15211724 0.80 TSHR (0.46) TSHRLMNADNM1ZDHHC20ZDHHC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104884431-B Nitrile compound KAO CORP. (JP) 2016-11-30 CN disclosed