Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004405 | 0.86 | HTR2A (0.73) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL28698891 | 0.84 | KDM4E (0.67) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL28991551 | 0.84 | KDM4E (0.67) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL5635157 | 0.83 | HTR2A (0.65) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL29834888 | 0.83 | HTR2A (0.65) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL27598427 | 0.82 | HTR2A (0.63) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL7281434 | 0.82 | HTR2A (0.63) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL10146987 | 0.81 | HTR2A (0.67) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL2504591 | 0.81 | KDM4E (0.67) | KDM4EHSD17B10HPGDHTR2AGPR84 | |
| SCHEMBL8243638 | 0.81 | HTR2A (0.61) | KDM4EHSD17B10HPGDHTR2AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106170290-A | Substituted di-amino-pyrimidine based compound, combinations thereof and treatment method thereof | 西格诺药品有限公司 | 2016-11-30 | — | — | CN | disclosed |