Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL27991928 | 0.97 | HIF1A (0.55) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL28008315 | 0.95 | HIF1A (0.52) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL26598238 | 0.95 | HIF1A (0.57) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL42887 | 0.95 | HIF1A (0.57) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Phosphine SCHEMBL27584741 | 0.92 | HIF1A (0.55) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Phosphine SCHEMBL28150214 | 0.92 | HIF1A (0.55) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8722010 | 0.92 | HIF1A (0.55) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL29563765 | 0.92 | HIF1A (0.60) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL2649213 | 0.90 | HIF1A (0.52) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Methyl Alcohol SCHEMBL27789701 | 0.90 | HIF1A (0.52) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108787378-A | A kind of device and method of powder coating solidification for artificial board surface | 佛山宜可居新材料有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-209456355-U | A kind of Industrial Stoves tri-phenyl-ethyl phosphonium bromide desulfurization and denitrification integral system | 江西肯特化学有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-110291172-A | Method for reducing permeability of a subterranean formation to water-based fluids | 陶氏环球技术有限责任公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-106409150-A | WINDOW FILM AND FLEXIBLE DISPLAY INCLUDING THE SAME | 三星SDI株式会社 | 2017-02-15 | — | — | CN | disclosed |