Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28304131 | 0.98 | BIRC2 (0.33) | BIRC2 | |
| SCHEMBL1189608 | 0.93 | — | — | |
| SCHEMBL1188965 | 0.93 | — | — | |
| SCHEMBL82072 | 0.93 | — | — | |
| SCHEMBL8207333 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL17272031 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL22576775 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL1191130 | 0.90 | BIRC2 (0.36) | BIRC2 | |
| Hydrochloric Acid SCHEMBL1191003 | 0.90 | BIRC2 (0.36) | BIRC2 | |
| Hydrochloric Acid SCHEMBL1188804 | 0.90 | BIRC2 (0.36) | BIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106459039-A | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds as JAK inhibitors | 豪夫迈·罗氏有限公司 | 2017-02-22 | — | — | CN | disclosed |