Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenacetin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.93 |
| ▸ | MEN1 | O00255 | 2/20 | 0.93 |
| ▸ | LMNA | P02545 | 2/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.93 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.93 |
| ▸ | MAPT | P10636 | 7/20 | 0.84 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenacetin SCHEMBL18894356 | 0.96 | KMT2A (1.00) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL23280 | 0.96 | KMT2A (1.00) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL28498098 | 0.95 | KMT2A (0.96) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL28630552 | 0.95 | KMT2A (0.96) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL28388594 | 0.95 | KMT2A (0.96) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL27595223 | 0.95 | KMT2A (0.96) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL28570302 | 0.95 | KMT2A (0.96) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL10630698 | 0.95 | KMT2A (0.96) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL5630647 | 0.90 | KMT2A (0.87) | KMT2AMEN1LMNACYP1A2TDP1 | |
| Phenacetin SCHEMBL27622268 | 0.90 | KMT2A (0.87) | KMT2AMEN1LMNACYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478445-A | A kind of preparation method of phenacetin micropowder | 华中药业股份有限公司 | 2017-03-08 | — | — | CN | claimed |
| CN-106478445-A | A kind of preparation method of phenacetin micropowder | 华中药业股份有限公司 | 2017-03-08 | — | — | CN | disclosed |
| CN-106478445-A | A kind of preparation method of phenacetin micropowder | 华中药业股份有限公司 | 2017-03-08 | — | — | CN | disclosed |