Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28126289 | 1.00 | KDM5A (0.47) | KDM5ADDB1CRBNACHETNK2 | |
| SCHEMBL28824170 | 0.94 | KDM5A (0.42) | KDM5ADDB1CRBNACHEEGFR | |
| SCHEMBL28135516 | 0.94 | KDM5A (0.42) | KDM5ADDB1CRBNACHEEGFR | |
| SCHEMBL27834485 | 0.92 | KDM5A (0.43) | KDM5ADDB1CRBNACHETNK2 | |
| SCHEMBL27964370 | 0.91 | KDM5A (0.39) | KDM5ADDB1CRBNACHE | |
| SCHEMBL14764015 | 0.89 | KDM5A (0.44) | KDM5ADDB1CRBNACHETNK2 | |
| SCHEMBL27945236 | 0.88 | KDM5A (0.41) | KDM5ADDB1CRBNACHETNK2 | |
| SCHEMBL14764140 | 0.81 | KDM5A (0.41) | KDM5ADDB1CRBNACHETNK2 | |
| SCHEMBL28104949 | 0.81 | CYP2C19 (0.34) | KDM5ADDB1CRBNACHEMAP3K7 | |
| SCHEMBL28125974 | 0.81 | CYP2C19 (0.34) | KDM5ADDB1CRBNACHEMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109096274-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-28 | — | — | CN | disclosed |
| CN-108947913-A | It can be used for treating the aryl-linking compound of human tumor, neurology and amynologic disease | 比奥根MA公司 | 2018-12-07 | — | — | CN | disclosed |
| CN-106459002-A | Biaryl compounds useful in the treatment of human oncological, neurological and immunological diseases | 比奥根MA公司 | 2017-02-22 | — | — | CN | disclosed |