SCHEMBL28129133

SCHEMBL28129133

Nc1cccc(C(F)(F)F)c1.[NaH]

nearest known ligand 0.95

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.95
MAPK1 P28482 1/20 0.95
PTGS1 P23219 4/20 0.51
CYP3A4 P08684 1/20 0.50
CASP1 P29466 1/20 0.50
RECQL P46063 1/20 0.50
TAAR1 Q96RJ0 1/20 0.48
MAOB P27338 2/20 0.47
IDO1 P14902 2/20 0.47
HTR3E A5X5Y0 1/20 0.47
HTR3B O95264 1/20 0.47
HTR3A P46098 1/20 0.47
HTR3D Q70Z44 1/20 0.47
HTR3C Q8WXA8 1/20 0.47
CES2 O00748 1/20 0.47
MGLL Q99685 1/20 0.47
ALDH1A1 P00352 2/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39591 0.98 TSHR (1.00) TSHRMAPK1PTGS1CYP3A4CASP1
SCHEMBL29410732 0.98 TSHR (1.00) TSHRMAPK1PTGS1CYP3A4CASP1
Hydrochloric Acid SCHEMBL4372377 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Hydrochloric Acid SCHEMBL30953679 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Water SCHEMBL27580150 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Hydrochloric Acid SCHEMBL2790297 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Water SCHEMBL27781603 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Water SCHEMBL7109306 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Iodide SCHEMBL31305312 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1
Fluoride SCHEMBL10897661 0.95 TSHR (0.95) TSHRMAPK1PTGS1CYP3A4CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106478464-A A kind of preparation method of 2 fluorine, 6 trifluoromethyl benzene sulfonyl chloride 黄河三角洲京博化工研究院有限公司 2017-03-08 CN disclosed