Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.44 |
| ▸ | JAK2 | O60674 | 11/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28129632 | 1.00 | NTRK1 (0.44) | NTRK1JAK2ROS1 | |
| SCHEMBL16293124 | 0.88 | NTRK1 (0.45) | NTRK1JAK2 | |
| SCHEMBL28129069 | 0.88 | NTRK1 (0.47) | NTRK1JAK2 | |
| SCHEMBL28129071 | 0.88 | NTRK1 (0.47) | NTRK1JAK2 | |
| SCHEMBL28129546 | 0.85 | NTRK1 (0.44) | NTRK1JAK2 | |
| SCHEMBL28129547 | 0.85 | NTRK1 (0.44) | NTRK1JAK2 | |
| SCHEMBL28129544 | 0.82 | NTRK1 (0.47) | NTRK1JAK2 | |
| SCHEMBL21097305 | 0.82 | NTRK1 (0.43) | NTRK1JAK2ROS1 | |
| SCHEMBL21097306 | 0.82 | NTRK1 (0.43) | NTRK1JAK2ROS1 | |
| SCHEMBL21097300 | 0.81 | NTRK1 (0.45) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104114553-B | Substituted pyrazolo [1,5 a] pyridine as tropomyosin receptor kinase (Trk) inhibitor | 雷迪博士实验室有限公司 | 2017-03-01 | — | — | CN | claimed |