Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.49 |
| ▸ | MARS1 | P56192 | 3/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522534 | 0.84 | HDAC6 (0.47) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28013853 | 0.83 | HDAC6 (0.60) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17373675 | 0.82 | SMN1; SMN2 (0.59) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1414029 | 0.78 | HDAC3 (0.56) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30406016 | 0.77 | HDAC6 (0.44) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2518490 | 0.77 | HDAC6 (0.44) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29514399 | 0.76 | HDAC6 (0.43) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28946897 | 0.76 | HDAC6 (0.43) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL25229993 | 0.75 | SMN1; SMN2 (0.57) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28013855 | 0.73 | HDAC6 (0.59) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661056-B | As Casein kinase 1 δ/epsilon inhibitor Imidazopyridazine derivative | 百时美施贵宝公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106661056-A | Imidazo-pyridazne derivatives as casein kinase 1 delta/epsilon inhibitors | 百时美施贵宝公司 | 2017-05-10 | — | — | CN | disclosed |