Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2815178 | 1.00 | KDM4E (0.51) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL3646261 | 0.83 | KDM4E (0.51) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL13883984 | 0.79 | KDM4E (0.53) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL2815998 | 0.78 | KDM4E (0.46) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL2815859 | 0.78 | KDM4E (0.46) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL3655710 | 0.75 | KDM4E (0.49) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL8111822 | 0.75 | KDM4E (0.55) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL2321907 | 0.74 | KDM4E (0.48) | KDM4EL3MBTL1NPSR1ALDH1A1MAPK1 | |
| SCHEMBL2815065 | 0.73 | KDM4E (0.50) | KDM4EL3MBTL1NPSR1TDP1RXFP1 | |
| SCHEMBL17014813 | 0.73 | KDM4E (0.70) | KDM4EL3MBTL1NPSR1TDP1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205602-B1 | IMIDAZO[1,2-A]QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS | UNIV MONTPELLIER (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-8378098-B2 | Imidazol[1,2-α]quinoxalines and derivatives for the treatment of cancers | UNIVERSITE DE MONTPELLIER I (FR) | 2013-02-19 | — | — | US | disclosed |
| US-20100249142-A1 | IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS | UNIVERSITE DE MONTPELLIER I | 2010-09-30 | — | — | US | disclosed |
| EP-2205602-A1 | IMIDAZOÝL,2- ¨QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS | Université de Montpellier I (FR) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043934-A1 | IMIDAZO[L,2-α]QUINOXALINES AND DERIVATIVES THEREOF FOR TREATING CANCERS | UNIVERSITE DE MONTPELLIER I (FR) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249142-A1 | IMIDAZOL[1,2-alpha]QUINOXALINES AND DERIVATIVES FOR THE TREATMENT OF CANCERS | IDH3A, NRAS, KRAS | KDM4E 2878/4885L3MBTL1 3674/4885NPSR1 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.