SCHEMBL28146181

SCHEMBL28146181

COc1cccc2c1=c1c(OC)cccc1=c1cccc(Br)c1=c1c(Br)cccc1=2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.42
CA2 P00918 4/20 0.42
CA7 P43166 3/20 0.42
CA9 Q16790 3/20 0.42
CA12 O43570 2/20 0.42
CA14 Q9ULX7 2/20 0.42
CA4 P22748 1/20 0.42
LY96 Q9Y6Y9 1/20 0.40
MAPT P10636 3/20 0.39
HPGD P15428 3/20 0.39
ALDH1A1 P00352 3/20 0.39
MAPK1 P28482 3/20 0.39
TP53 P04637 2/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CYP3A4 P08684 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NQO2 P16083 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10752651 0.87 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL7950717 0.76 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL5576497 0.76 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL7930018 0.73 CA1 (0.50) CA1CA2CA7CA9CA12
SCHEMBL29424769 0.72
SCHEMBL57602 0.72
SCHEMBL29427102 0.71 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL29732515 0.71 SMN1; SMN2 (0.50) CA1CA2CA7CA9CA12
SCHEMBL5568763 0.71 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL1627615 0.71 SMN1; SMN2 (0.50) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106631726-A Synthetic method for optically pure double-helix oligomeric tetra-benzocyclooctene substances 香港中文大学深圳研究院 2017-05-10 CN disclosed