Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Benzamidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.90 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.90 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.90 |
| ▸ | C1S | P09871 | 2/20 | 0.90 |
| ▸ | RECQL | P46063 | 1/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.90 |
| ▸ | F2 | P00734 | 4/20 | 0.89 |
| ▸ | F10 | P00742 | 1/20 | 0.89 |
| ▸ | F12 | P00748 | 1/20 | 0.89 |
| ▸ | F7 | P08709 | 1/20 | 0.89 |
| ▸ | F3 | P13726 | 1/20 | 0.89 |
| ▸ | PKM | P14618 | 1/20 | 0.89 |
| ▸ | WDR5 | P61964 | 1/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | PLG | P00747 | 2/20 | 0.54 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | MASP2 | O00187 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamidine SCHEMBL7103811 | 0.97 | F2 (0.94) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL29191424 | 0.97 | BLM (1.00) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL6861235 | 0.97 | BLM (1.00) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL61379 | 0.97 | BLM (1.00) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL27303891 | 0.97 | BLM (1.00) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL23235801 | 0.97 | BLM (1.00) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL29191425 | 0.94 | BLM (0.94) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL596593 | 0.94 | PRSS1 (1.00) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL28224057 | 0.94 | BLM (0.94) | BLMPRSS1PRSS3PRSS2C1S | |
| Benzamidine SCHEMBL9040332 | 0.94 | PRSS1 (1.00) | BLMPRSS1PRSS3PRSS2C1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632106-A | Synthetic method of asymmetric 1,2,4-triazole derivatives | 安徽师范大学 | 2017-05-10 | — | — | CN | disclosed |