Known targets — ChEMBL curated mechanism
CSF1RFLT1FLT4KDRKITPDGFRAPDGFRB
The experimentally established mechanism targets of Vatalanib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 known ✓ | P17948 | 19/20 | 0.97 |
| ▸ | KDR known ✓ | P35968 | 19/20 | 0.97 |
| ▸ | PDGFRB known ✓ | P09619 | 9/20 | 0.97 |
| ▸ | KIT known ✓ | P10721 | 8/20 | 0.97 |
| ▸ | CSF1R known ✓ | P07333 | 2/20 | 0.97 |
| ▸ | FLT4 known ✓ | P35916 | 2/20 | 0.97 |
| ▸ | PDGFRA known ✓ | P16234 | 1/20 | 0.97 |
| ▸ | CIT | O14578 | 1/20 | 0.97 |
| ▸ | EGFR | P00533 | 1/20 | 0.97 |
| ▸ | HLA-A | P04439 | 1/20 | 0.97 |
| ▸ | RET | P07949 | 1/20 | 0.97 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.97 |
| ▸ | FRK | P42685 | 1/20 | 0.97 |
| ▸ | CDK8 | P49336 | 1/20 | 0.97 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.97 |
| ▸ | STK3 | Q13188 | 1/20 | 0.97 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.97 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.97 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.97 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vatalanib SCHEMBL29350047 | 0.99 | FLT1 (1.00) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL18286 | 0.99 | FLT1 (1.00) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL905616 | 0.97 | FLT1 (0.97) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL6131017 | 0.97 | FLT1 (0.97) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL905598 | 0.97 | FLT1 (0.97) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL6131019 | 0.97 | FLT1 (0.97) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL6131018 | 0.97 | FLT1 (0.97) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL29633763 | 0.97 | FLT1 (0.97) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL6605579 | 0.92 | KDR (0.88) | FLT1KDRPDGFRBKITCSF1R | |
| Vatalanib SCHEMBL6607537 | 0.91 | KDR (0.84) | FLT1KDRPDGFRBKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106661039-B | 2 (TYK2) inhibitor of tyrosine protein matter kinases and its purposes | 林伯士拉克许米公司 | 2019-09-13 | — | — | CN | disclosed |
| CN-106661039-A | TYK2 inhibitors and uses thereof | 林伯士拉克许米公司 | 2017-05-10 | — | — | CN | disclosed |