Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.50 |
| ▸ | RAB9A | P51151 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28147512 | 0.90 | NPC1 (0.47) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| Maleic Acid SCHEMBL28146438 | 0.88 | NPC1 (0.49) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| Cinnamic Acid SCHEMBL28146437 | 0.80 | ESR1 (0.56) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL12338160 | 0.80 | NPC1 (0.51) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL3780938 | 0.79 | NPC1 (0.56) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL30366677 | 0.78 | NPC1 (0.47) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL22341606 | 0.76 | NPC1 (0.58) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL3780111 | 0.76 | FFAR1 (0.49) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL3785463 | 0.76 | NPC1 (0.48) | NPC1RAB9AKDM4EL3MBTL1HKDC1 | |
| SCHEMBL212553 | 0.75 | NPC1 (0.61) | NPC1RAB9AKDM4EL3MBTL1HKDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108799632-A | A kind of high intensity is hinged constant supporting spring hanger | 倍德力能源装备（江苏）有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-108541092-A | Single head U-tube and straight-bar knockdown type electric heating tube | 镇江市恒升达化工科技有限公司 | 2018-09-14 | — | — | CN | claimed |
| CN-108302237-A | A kind of valve seal gland and its production technology | 江苏盐发机械有限公司 | 2018-07-20 | — | — | CN | claimed |
| CN-107868495-A | A kind of high pressure resistant insulation electric pump and its Surface heat-treatent modified technique | 博维恩冷冻科技（苏州）有限公司 | 2018-04-03 | — | — | CN | claimed |
| CN-107387508-A | A kind of high pressure resistant flange and its production technology | 江苏盐发机械有限公司 | 2017-11-24 | — | — | CN | claimed |
| CN-107234552-A | A kind of anti-oxidant phenolic resin emery cloth of high-strength waterproof and preparation method thereof | 江苏省江南新型复合研磨材料及制品工程技术研究中心有限公司 | 2017-10-10 | — | — | CN | claimed |
| CN-106700832-A | Damp-proof and wear-resistant switch and preparation method thereof | 苏州富艾姆工业设备有限公司 | 2017-05-24 | — | — | CN | claimed |
| CN-106626665-A | Nano insulating sealing strip and preparation method thereof | 苏州富艾姆工业设备有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-108799632-A | A kind of high intensity is hinged constant supporting spring hanger | 倍德力能源装备（江苏）有限公司 | 2018-11-13 | — | — | CN | disclosed |
| CN-108541092-A | Single head U-tube and straight-bar knockdown type electric heating tube | 镇江市恒升达化工科技有限公司 | 2018-09-14 | — | — | CN | disclosed |
| CN-107936658-A | A kind of anti-corrosion electric pump case and its casting technique | 博维恩冷冻科技（苏州）有限公司 | 2018-04-20 | — | — | CN | disclosed |
| CN-107868495-A | A kind of high pressure resistant insulation electric pump and its Surface heat-treatent modified technique | 博维恩冷冻科技（苏州）有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-107234552-A | A kind of anti-oxidant phenolic resin emery cloth of high-strength waterproof and preparation method thereof | 江苏省江南新型复合研磨材料及制品工程技术研究中心有限公司 | 2017-10-10 | — | — | CN | disclosed |
| CN-106700832-A | Damp-proof and wear-resistant switch and preparation method thereof | 苏州富艾姆工业设备有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-106626665-A | Nano insulating sealing strip and preparation method thereof | 苏州富艾姆工业设备有限公司 | 2017-05-10 | — | — | CN | disclosed |