Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28156730 | 0.87 | KDM4E (0.49) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL28157299 | 0.82 | MAPT (0.66) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL16246265 | 0.81 | MAPT (0.56) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL28846328 | 0.77 | HPGD (0.48) | MAPTPOLBSMN1; SMN2HSD17B10TP53 | |
| SCHEMBL16088763 | 0.75 | MAPT (0.62) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL16246474 | 0.75 | MAPT (0.59) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL28157282 | 0.73 | MAPT (0.52) | MAPTTSHRSMN1; SMN2MAPK1TP53 | |
| SCHEMBL28846473 | 0.72 | TSHR (0.51) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL16387392 | 0.72 | FLT3 (0.51) | MAPTPOLBTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL28157411 | 0.71 | KDM1A (0.55) | MAPTPOLBSMN1; SMN2HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105531268-B | Noval chemical compound and its pharmaceutical composition for treating cystic fibrosis | 加拉佩格斯股份有限公司 | 2017-09-12 | — | — | CN | disclosed |