Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.49 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28301842 | 0.79 | MTOR (0.57) | MTORPIK3CAMAP3K12PIK3R1PIK3CB | |
| SCHEMBL28166663 | 0.77 | PIK3CA (0.67) | MTORPIK3CAMAP3K12PIK3R1PIK3CB | |
| SCHEMBL28162008 | 0.77 | MTOR (0.52) | MTORPIK3CAMAP3K12PIK3R1PIK3CB | |
| SCHEMBL27796330 | 0.76 | MTOR (0.67) | MTORPIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL28161448 | 0.74 | PIK3CA (0.67) | MTORPIK3CAMAP3K12PIK3CBPIK3CG | |
| SCHEMBL9003193 | 0.68 | KMT2A (0.76) | MTORPIK3CAMAP3K12PIK3CBKMT2A | |
| SCHEMBL15789552 | 0.67 | PIK3CA (0.63) | MTORPIK3CAMAP3K12PIK3R1PIK3CB | |
| SCHEMBL16035197 | 0.66 | PIK3CA (0.59) | MTORPIK3CAMAP3K12PIK3R1PIK3CB | |
| SCHEMBL10327997 | 0.66 | PIK3CA (1.00) | MTORPIK3CAMAP3K12PIK3R1PIK3CB | |
| SCHEMBL13016719 | 0.66 | PIK3CA (0.78) | MTORPIK3CAMAP3K12PIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001317-A | High selectivity substituted uracil PI3K inhibitor | 山东轩竹医药科技有限公司 | 2017-08-01 | — | — | CN | disclosed |