Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744837 | 0.83 | HRH2 (0.44) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL12226501 | 0.83 | HRH2 (0.44) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL12226499 | 0.83 | HRH2 (0.44) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL29954077 | 0.77 | HSD17B10 (0.41) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL2362299 | 0.77 | HSD17B10 (0.41) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL2362301 | 0.77 | HSD17B10 (0.41) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL5848866 | 0.77 | KDM4E (0.45) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL1063621 | 0.77 | KDM4E (0.45) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL1006226 | 0.77 | KDM4E (0.45) | HRH2HRH1GNAI3GNAO1GNAI1 | |
| SCHEMBL14306821 | 0.75 | SMN1; SMN2 (0.45) | HRH2HRH1GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108430992-A | QUINOLINE-3-CARBOXAMIDES AS H-PGDS INHIBITORS | 阿斯特克斯医疗公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-105399698-B | Aromatic heterocyclic derivatives and its application in drug | 广东东阳光药业有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-107912040-A | Pyrrolidine Amide Compounds As Histone Demethylase Inhibitors | 基因泰克公司 | 2018-04-13 | — | — | CN | disclosed |
| CN-107793395-A | Fibroblast growth factor acceptor inhibitor and application thereof | 南京药捷安康生物科技有限公司 | 2018-03-13 | — | — | CN | disclosed |
| CN-107635986-A | Substituted quinoxaline derivatives | 赛尔维他股份公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-107484415-A | 1-cyanopyrrolidine compounds as USP30 inhibitors | 特殊治疗有限公司 | 2017-12-15 | — | — | CN | disclosed |
| CN-105473575-B | Benzimidazolyl-methylurea derivatives as ALX receptor agonists | 爱杜西亚药品有限公司 | 2017-11-24 | — | — | CN | disclosed |
| CN-107108583-A | Indole carboxamide compounds useful as kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107074804-A | Carbazole derivates | 百时美施贵宝公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-106883194-A | Oxadiazole analog derivative, its preparation method and its in application pharmaceutically | 江苏恒瑞医药股份有限公司 | 2017-06-23 | — | — | CN | disclosed |
| CN-103998042-B | Use of inhibitors of the activity or function of PI3K | 诺华股份有限公司 | 2016-12-28 | — | — | CN | disclosed |
| CN-102971317-B | tetrahydro-pyrido-pyrimidine derivatives | NOVARTIS AG (CH) | 2016-01-20 | — | — | CN | disclosed |
| CN-103998042-A | Use of inhibitors of the activity or function of PI3K | NOVARTIS AG | 2014-08-20 | — | — | CN | disclosed |
| CN-102971317-A | Tetrahydro-pyrido-pyrimidine derivatives | NOVARTIS AG | 2013-03-13 | — | — | CN | disclosed |