SCHEMBL28166753

SCHEMBL28166753

O=C(Cl)c1cc(Br)cc(Br)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C4 P17516 1/20 0.45
AKR1C3 P42330 1/20 0.45
AKR1C2 P52895 1/20 0.45
AKR1C1 Q04828 1/20 0.45
HSD17B10 Q99714 1/20 0.40
HSPD1 P10809 2/20 0.37
HSPE1 P61604 2/20 0.37
GPR35 Q9HC97 3/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2C9 P11712 2/20 0.36
MEN1 O00255 1/20 0.36
EGFR P00533 1/20 0.36
LMNA P02545 1/20 0.36
ERBB2 P04626 1/20 0.36
LCK P06239 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30519485 0.83 AKR1C3 (0.61) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL1228193 0.83 AKR1C3 (0.61) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL7682107 0.80 AKR1C3 (0.47) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL11760933 0.78 AKR1C4 (0.67) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL24665431 0.77 AKR1C3 (0.44) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL11624384 0.77 AKR1C4 (0.44) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL5294872 0.77 AKR1C3 (0.41) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL1228180 0.76 HSD17B10 (0.47) AKR1C4AKR1C3AKR1C2AKR1C1HSD17B10
SCHEMBL14126484 0.75 HSD17B10 (0.42) HSD17B10ALDH1A1CYP1A2CYP2C9LCK
SCHEMBL28174295 0.75 CA1 (0.33) LMNAFLT1FLT4KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105358533-B Heterocyclic compound and organic light-emitting device using the same 喜星素材株式会社 2018-08-28 CN disclosed
CN-108191761-A Heterocyclic compound and use its organic luminescent device 喜星素材株式会社 2018-06-22 CN disclosed
CN-107001324-A Nitrogen-containing polycyclic compound and organic light-emitting device using same 喜星素材株式会社 2017-08-01 CN disclosed