Histidine

Histidine

SCHEMBL28178306

NC(Cc1c[nH]cn1)C(=O)O.O=C(O)CNc1ccccc1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.40
CYP1A2 P05177 1/20 0.40
ALPI P09923 1/20 0.40
PKM P14618 1/20 0.40
PTGS1 P23219 1/20 0.40
XIAP P98170 1/20 0.40
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
MPO P05164 1/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.38
BLM P54132 1/20 0.38
PMP22 Q01453 1/20 0.38
KMT2A Q03164 1/20 0.38
HIF1A Q16665 1/20 0.38
CYP3A4 P08684 1/20 0.35
LTA4H P09960 1/20 0.35
TPH1 P17752 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL7562388 0.84 SLC7A5 (0.40) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL28341949 0.84 SLC7A5 (0.40) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL209483 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL3985696 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL670490 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL16893957 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL139654 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL16893958 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
Histidine SCHEMBL94550 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1
D-Histidine SCHEMBL8002457 0.84 SLC7A5 (0.46) SLC7A5CYP1A2ALPIPKMPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107118127-B Amino-acid schiff base and its synthetic method and application 哈尔滨理工大学 2019-01-04 CN disclosed
CN-107118127-A Amino-acid schiff base and its synthetic method and application 哈尔滨理工大学 2017-09-01 CN disclosed