Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.36 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL8369937 | 0.83 | SLC7A5 (0.39) | PTGS1LMNABLMNR1I2ADRA1A | |
| Lactic Acid SCHEMBL5072826 | 0.76 | TP53 (0.65) | TP53PTGS2PTGS1LMNACYP2C9 | |
| Catechol SCHEMBL17999115 | 0.75 | TP53 (0.55) | TP53PTGS2PTGS1LMNABLM | |
| Lactic Acid SCHEMBL8376573 | 0.74 | TP53 (0.85) | TP53PTGS2LMNATSHRMAPK1 | |
| L-Lactic Acid SCHEMBL13165963 | 0.74 | — | — | |
| Lactic Acid SCHEMBL9066424 | 0.74 | — | — | |
| L-Lactic Acid SCHEMBL16958 | 0.74 | — | — | |
| Lactic Acid SCHEMBL180386 | 0.74 | TP53 (1.00) | TP53LMNATSHR | |
| Lactic Acid SCHEMBL1412661 | 0.74 | TP53 (1.00) | TP53LMNATSHR | |
| Lactic Acid SCHEMBL9066423 | 0.74 | TP53 (1.00) | TP53LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107299072-A | Engineering bacterium and application thereof | 江南大学 | 2017-10-27 | — | — | CN | disclosed |