SCHEMBL28186

SCHEMBL28186

[CH]1CNCCS1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL567117 0.94
SCHEMBL173784 0.81
SCHEMBL3275367 0.79
SCHEMBL3277073 0.75
SCHEMBL3339679 0.73
SCHEMBL1780353 0.69
SCHEMBL23911 0.65
SCHEMBL342826 0.64
SCHEMBL6419549 0.61
SCHEMBL3277565 0.61

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6607 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024130342-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS UNIQUEST PTY LIMITED (AU) 2024-06-27 WO claimed
US-20240190869-A1 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES PFIZER (US) 2024-06-13 US claimed
CN-117534663-A Fused tricyclic derivatives and their pharmaceutical use 正大天晴药业集团股份有限公司 2024-02-09 CN claimed
US-20230322745-A1 FUSED TRICYCLIC DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2023-10-12 US claimed
EP-4219485-A1 FUSED TRICYCLIC DERIVATIVE AND PHARMACEUTICAL APPLICATION THEREOF CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2023-08-02 EP claimed
CN-116457357-A Fused tricyclic derivatives and their pharmaceutical use 正大天晴药业集团股份有限公司 2023-07-18 CN claimed
CN-107787322-B Tricyclic compounds and their use as phosphodiesterase inhibitors 辉瑞大药厂 2023-07-07 CN claimed
US-20230192690-A1 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES PFIZER (US) 2023-06-22 US claimed
US-20230158028-A1 COMPOUNDS AND METHODS FOR INDUCING UCP1 EXPRESSION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-05-25 US claimed
WO-2023074847-A1 NOVEL SPIRO COMPOUND 田辺三菱製薬株式会社 2023-05-04 WO claimed
EP-0633886-A1 PHARMACEUTICALLY ACTIVE BICYCLIC-HETEROCYCLIC AMINES PHARMACIA &amp; UPJOHN COMPANY (US) 1995-01-18 EP claimed
EP-0280627-B1 DERIVATIVES OF N-SUBSTITUTED ALPHA-MERCAPTOMETHYL-BENZENE-PROPANAMIDE, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1993-04-21 EP claimed
EP-0300865-B1 DERIVATIVES OF N-AMINOBUTYL-N-PHENYL ARYL AMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SYNTHELABO (FR) 1992-03-18 EP claimed
US-4987130-A ANTIARRHYTHMIA AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1991-01-22 US claimed
EP-0157762-B1 NEW SUBSTITUTED PIPERIDINOGUANIDINES, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOUCHARA S.A. (FR) 1990-08-08 EP claimed
US-4839358-A ANALGESICS, ANTIDEPRESSANTS, ANTIANXIETY AGENTS ROUSSEL UCLAF (FR) 1989-06-13 US claimed
WO-1988000587-A2 5-HETERO- OR ARYL-SUBSTITUTED-IMIDAZO[2,1-a]ISOQUINOLINES SANDOZ AG (CH) 1988-01-28 WO claimed
US-4638000-A HYPOTENSIVES, ANGIOTENSIN INHIBITORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-01-20 US claimed
EP-0072710-A1 Carbapenem derivatives, their preparation and compositions containing them SANKYO COMPANY LIMITED (JP) 1983-02-23 EP claimed
EP-0018735-A1 1,8-Naphthyridine derivatives, their preparation, pharmaceutical compositions containing them AMERICAN HOME PRODUCTS CORPORATION (US) 1980-11-12 EP claimed