Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.62 |
| ▸ | RAF1 | P04049 | 6/20 | 0.60 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | CDK8 | P49336 | 4/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | MUSK | O15146 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282580 | 0.96 | KDR (0.66) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL282625 | 0.87 | CDK8 (0.61) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL281699 | 0.86 | RAF1 (0.57) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL717714 | 0.84 | CSF1R (0.49) | KDRPDGFRAFLT3CSF1R | |
| SCHEMBL4344749 | 0.77 | RAF1 (0.78) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL30462521 | 0.76 | RAF1 (0.73) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL936533 | 0.76 | RAF1 (0.73) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL3408496 | 0.75 | RAF1 (0.85) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL282579 | 0.75 | CDK8 (0.61) | KDRRAF1KITPDGFRBPDGFRA | |
| SCHEMBL2936061 | 0.75 | KDR (0.69) | KDRRAF1KITPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428506-A1 | HETEROCYCLIC SUBSTITUTED ACARDITE DERIVATES AND USE THEREOF | Jiangsu Provincial Institute Of Materia Medica Co. (CN) | 2012-03-14 | — | — | EP | claimed |