Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL2692237 | 0.91 | — | — | |
| Dimethylformamide SCHEMBL28283961 | 0.88 | TSHR (0.60) | TSHRFFAR3LCKFYNALDH1A1 | |
| Dimethylformamide SCHEMBL10825078 | 0.88 | TSHR (0.60) | TSHRFFAR3LCKFYNALDH1A1 | |
| Dimethylformamide SCHEMBL8899886 | 0.88 | TSHR (0.60) | TSHRFFAR3LCKFYNALDH1A1 | |
| Dimethylformamide SCHEMBL8768884 | 0.88 | TSHR (0.60) | TSHRFFAR3LCKFYNALDH1A1 | |
| Dimethylformamide SCHEMBL28249838 | 0.88 | TSHR (0.60) | TSHRFFAR3LCKFYNALDH1A1 | |
| Dimethylformamide SCHEMBL10800675 | 0.88 | TSHR (0.60) | TSHRFFAR3LCKFYNALDH1A1 | |
| Dimethylformamide SCHEMBL28185671 | 0.85 | TSHR (0.56) | TSHRFFAR3LCKFYN | |
| Dimethylformamide SCHEMBL2145949 | 0.84 | — | — | |
| Dimethylformamide SCHEMBL27598913 | 0.82 | TSHR (0.53) | TSHRFFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579481-B | Photocurable resin composition and cured film thereof | 哈利玛化成株式会社 | 2018-01-09 | — | — | CN | disclosed |