Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24075950 | 0.82 | KDM4E (0.55) | HTTPARP14KDM4EALDH1A1HPGD | |
| SCHEMBL31023147 | 0.81 | HAT1 (0.49) | HTTSMN1; SMN2PARP14KDM4EALDH1A1 | |
| SCHEMBL12748340 | 0.81 | HAT1 (0.49) | HTTSMN1; SMN2PARP14KDM4EALDH1A1 | |
| SCHEMBL2811213 | 0.79 | HTT (0.59) | HTTSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL29415445 | 0.79 | HTT (0.59) | HTTSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL19328315 | 0.77 | AKR1C4 (0.38) | HTTSMN1; SMN2PARP14KDM4EKMT2A | |
| SCHEMBL18589536 | 0.76 | KDM4E (0.62) | HTTKDM4EALDH1A1HPGDPBRM1 | |
| SCHEMBL18999655 | 0.76 | PARP14 (0.50) | PARP14HPGDBRPF1 | |
| SCHEMBL23867569 | 0.76 | AHR (0.42) | HTTSMN1; SMN2PARP14KDM4EALDH1A1 | |
| SCHEMBL9288270 | 0.75 | AKR1C3 (0.39) | HTTSMN1; SMN2PARP14KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428733-A | CD38 inhibitor and treatment method | 葛兰素史克知识产权第二有限公司 | 2017-12-01 | — | — | CN | disclosed |