Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.66 |
| ▸ | FLT3 | P36888 | 10/20 | 0.66 |
| ▸ | KIT | P10721 | 9/20 | 0.66 |
| ▸ | FLT1 | P17948 | 6/20 | 0.60 |
| ▸ | CSF1R | P07333 | 5/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.60 |
| ▸ | FYN | P06241 | 4/20 | 0.60 |
| ▸ | FLT4 | P35916 | 4/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.60 |
| ▸ | LCK | P06239 | 3/20 | 0.60 |
| ▸ | LYN | P07948 | 3/20 | 0.60 |
| ▸ | BLK | P51451 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2818421 | 0.88 | KDR (0.57) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2819106 | 0.86 | KDR (0.64) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2817394 | 0.85 | KDR (0.70) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2816153 | 0.84 | KDR (0.68) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2817370 | 0.83 | KDR (0.67) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2819247 | 0.82 | KDR (0.62) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2818517 | 0.82 | KDR (0.53) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2821104 | 0.82 | KDR (0.70) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL2201444 | 0.82 | ADORA2A (0.41) | KDRFLT3KITCDK2ABL1 | |
| SCHEMBL1702977 | 0.82 | KDR (0.75) | KDRFLT3KITFLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061790-B1 | Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them | BAYER IP GMBH (DE) | 2014-08-13 | — | — | EP | disclosed |
| US-7846928-B2 | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | BAYER SCHERING PHARMA AG (DE) | 2010-12-07 | — | — | US | disclosed |
| US-7846928-B2 | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | BAYER SCHERING PHARMA AG (DE) | 2010-12-07 | — | — | US | disclosed |
| US-7846928-B2 | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | BAYER SCHERING PHARMA AG (DE) | 2010-12-07 | — | — | US | disclosed |
| CN-101528742-A | Substituted aminopyrazolopyridines and salts thereof, preparation thereof and pharmaceutical compositions comprising them | BAYER SCHERING PHARMA AG (DE) | 2009-09-09 | — | — | CN | disclosed |
| US-20080058326-A1 | SUBSTITUTED PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-03-06 | — | — | US | disclosed |
| US-20080058326-A1 | SUBSTITUTED PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-03-06 | — | — | US | disclosed |
| US-20080058326-A1 | SUBSTITUTED PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-03-06 | — | — | US | disclosed |
| WO-2007144204-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058326-A1 | SUBSTITUTED PYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | KDR, TIE1, FLT1 | KDR 1/4885FLT3 39/4885KIT 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.