SCHEMBL28197250

SCHEMBL28197250

Nc1nc(-c2ccc(F)cc2)nc2ccccc12

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 5/20 0.71
CYP1A2 P05177 5/20 0.71
CYP1B1 Q16678 5/20 0.71
ABCG2 Q9UNQ0 3/20 0.58
ADORA2A P29274 1/20 0.57
DPP4 P27487 1/20 0.55
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
ATM Q13315 1/20 0.53
MAPT P10636 2/20 0.52
LMNA P02545 1/20 0.52
DCPS Q96C86 1/20 0.52
KDM4E B2RXH2 1/20 0.51
ALDH1A1 P00352 1/20 0.51
PPARG P37231 1/20 0.51
NCOA2 Q15596 1/20 0.51
NCOA1 Q15788 1/20 0.51
NCOA3 Q9Y6Q9 1/20 0.51
KDM1A O60341 1/20 0.51
SCN9A Q15858 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14529287 0.87 CYP1A1 (0.77) CYP1A1CYP1A2CYP1B1ABCG2ADORA2A
SCHEMBL1395347 0.87 CYP1A1 (0.77) CYP1A1CYP1A2CYP1B1ABCG2ADORA2A
SCHEMBL29593101 0.87 CYP1A1 (0.77) CYP1A1CYP1A2CYP1B1ABCG2ADORA2A
SCHEMBL12443214 0.86 CYP1A2 (0.75) CYP1A1CYP1A2CYP1B1ABCG2ADORA2A
Hydrochloric Acid SCHEMBL29281621 0.85 CYP1A1 (0.77) CYP1A1CYP1A2CYP1B1ABCG2ADORA2A
SCHEMBL28773619 0.83 CYP1A1 (0.71) CYP1A1CYP1A2CYP1B1ABCG2DPP4
SCHEMBL28196630 0.83 CYP1A1 (0.97) CYP1A1CYP1A2CYP1B1ABCG2ADORA2A
SCHEMBL30843880 0.81 CYP1A1 (0.68) CYP1A1CYP1A2CYP1B1MEN1KMT2A
SCHEMBL11861155 0.81 CYP1A1 (0.68) CYP1A1CYP1A2CYP1B1MEN1KMT2A
SCHEMBL31061268 0.80 CYP1A1 (0.73) CYP1A1CYP1A2CYP1B1ABCG2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112334466-B Compounds of formula (I) CTXT私人有限公司 2025-05-30 CN disclosed
CN-107652275-A Quinazoline derivant and its production and use 沈阳工业大学 2018-02-02 CN disclosed