SCHEMBL28201989

SCHEMBL28201989

CC(C(=O)O)(C(=O)c1ccccc1)c1ccccc1.[NaH]

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 4/20 0.52
MAPT P10636 2/20 0.44
KMT2A Q03164 1/20 0.44
SRC P12931 1/20 0.43
CYP2C19 P33261 1/20 0.42
HIF1A Q16665 1/20 0.42
CYP1A2 P05177 3/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
ACHE P22303 1/20 0.41
TDP1 Q9NUW8 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6445601 0.98 CES1 (0.53) CES1MAPTKMT2ASRCCYP2C19
SCHEMBL27913155 0.90 CES1 (0.57) CES1MAPTKMT2ASRCCYP2C19
SCHEMBL21269891 0.85 MAPT (0.52) CES1MAPTKMT2ACYP2C19HIF1A
SCHEMBL15955114 0.84 CES1 (0.52) CES1MAPTKMT2ASRCCYP2C19
SCHEMBL27849259 0.84 CES1 (0.52) CES1MAPTKMT2ASRCCYP2C19
SCHEMBL28315679 0.83 MAPT (0.50) CES1MAPTKMT2ACYP2C19HIF1A
SCHEMBL28315854 0.83 MAPT (0.50) CES1MAPTKMT2ACYP2C19HIF1A
SCHEMBL1560417 0.83 MAPT (0.54) CES1MAPTKMT2ACYP2C19HIF1A
SCHEMBL7039215 0.82 MAPT (0.57) CES1MAPTKMT2ASRCCYP2C19
SCHEMBL21269958 0.81 MAPT (0.52) CES1MAPTKMT2ACYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107759466-A The method for splitting of (±) 2 (3 benzoyl) phenylpropionic acid 浙江瑞博制药有限公司 2018-03-06 CN claimed
CN-107759466-A The method for splitting of (±) 2 (3 benzoyl) phenylpropionic acid 浙江瑞博制药有限公司 2018-03-06 CN disclosed