Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.75 |
| ▸ | LMNA | P02545 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28206921 | 0.87 | KDM4E (0.92) | TRPV1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL28206905 | 0.87 | TRPV1 (0.74) | TRPV1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL28857503 | 0.83 | KDM4E (0.76) | TRPV1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL28206904 | 0.82 | TRPV1 (0.75) | TRPV1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL28207475 | 0.81 | TRPV1 (0.76) | TRPV1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL29748609 | 0.79 | KCNA5 (0.58) | LMNAALDH1A1KDM4ETSHRMAPK1 | |
| SCHEMBL28857676 | 0.79 | TRPV1 (0.71) | TRPV1LMNAALDH1A1KDM4EGAA | |
| SCHEMBL4601706 | 0.79 | DHODH (0.72) | TRPV1LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL5534950 | 0.78 | KDM4E (0.89) | LMNAALDH1A1KDM4EGAATP53 | |
| SCHEMBL28955062 | 0.78 | TRPV1 (0.75) | TRPV1LMNAALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107721919-A | Phenylchinoline class TRPV1 antagonists and its preparation method and application | 中国药科大学 | 2018-02-23 | — | — | CN | claimed |
| CN-107721919-A | Phenylchinoline class TRPV1 antagonists and its preparation method and application | 中国药科大学 | 2018-02-23 | — | — | CN | disclosed |