Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222209 | 0.93 | SLC18A3 (0.52) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Bromide SCHEMBL28484405 | 0.90 | SLC18A3 (0.50) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Ammonia Solution, Strong SCHEMBL28132614 | 0.90 | SLC18A3 (0.50) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Hydrochloric Acid SCHEMBL28486863 | 0.90 | SLC18A3 (0.50) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Trimethylammonium SCHEMBL28490265 | 0.84 | SLC18A3 (0.45) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Trimethylammonium SCHEMBL28484202 | 0.82 | SLC18A3 (0.43) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Trimethylammonium SCHEMBL28486865 | 0.82 | SLC18A3 (0.43) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| Trimethylammonium SCHEMBL28493688 | 0.82 | SLC18A3 (0.43) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| SCHEMBL10349649 | 0.77 | SLC6A2 (0.53) | SLC18A3SIGMAR1GBA1TSHRKMT2A | |
| SCHEMBL23951733 | 0.77 | GBA1 (0.50) | SLC18A3SIGMAR1GBA1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104860874-B | Bicyclic or tricyclic steric hindrance alkoxyamine and preparation method thereof | 巴斯夫欧洲公司 | 2018-04-17 | — | — | CN | disclosed |