Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23600955 | 0.81 | BRD4 (0.52) | IDO1PIK3C3BRD4GRIN2B | |
| SCHEMBL28215219 | 0.79 | PIK3C3 (0.48) | IDO1PIK3C3BRD4GRIN2B | |
| SCHEMBL4400758 | 0.78 | BRD4 (0.44) | IDO1PIK3C3BRD4FGFR1 | |
| SCHEMBL18363124 | 0.78 | AXL (0.54) | PIK3C3CDK8BRD4 | |
| SCHEMBL24721353 | 0.77 | CDK8 (0.50) | PIK3C3CDK8BRD4GRIN2B | |
| SCHEMBL28214614 | 0.74 | CDK8 (0.47) | PIK3C3CDK8BRD4GRIN2B | |
| SCHEMBL10269696 | 0.73 | NPC1 (0.62) | IDO1CDK8BRD4FGFR1 | |
| SCHEMBL5547358 | 0.72 | BCL2 (0.62) | IDO1FGFR1NISCH | |
| SCHEMBL29489424 | 0.72 | BCL2 (0.62) | IDO1FGFR1NISCH | |
| SCHEMBL22878658 | 0.71 | PIK3C3 (0.44) | PIK3C3CDK8BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026094-A | Substituted 4-azaindoles and their use as modulators of the G L UN2B receptor | 詹森药业有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-108026094-A | Substituted 4-azaindoles and their use as modulators of the G L UN2B receptor | 詹森药业有限公司 | 2018-05-11 | — | — | CN | disclosed |