Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21316005 | 0.77 | JAK2 (0.48) | HPGDJAK2JAK1TYK2JAK3 | |
| SCHEMBL16345943 | 0.77 | HRH3 (0.48) | HPGDJAK2JAK1TYK2JAK3 | |
| SCHEMBL16345139 | 0.77 | PDCD1 (0.49) | HPGDJAK2JAK1TYK2JAK3 | |
| SCHEMBL8150805 | 0.76 | HPGD (0.76) | HPGDPHGDHALDH1A1TSHRMEN1 | |
| SCHEMBL31622701 | 0.76 | PHGDH (0.53) | HPGDJAK2PHGDHHDAC4ERN1 | |
| SCHEMBL13952297 | 0.75 | HPGD (0.60) | HPGDPHGDHHDAC4RIPK1ERN1 | |
| SCHEMBL10720943 | 0.74 | PHGDH (0.81) | HPGDPHGDHALDH1A1TSHRKMT2A | |
| SCHEMBL31622597 | 0.74 | ERN1 (0.49) | HPGDJAK2PHGDHHDAC4ERN1 | |
| SCHEMBL31622683 | 0.73 | ERN1 (0.61) | HPGDJAK2PHGDHHDAC4ERN1 | |
| SCHEMBL26184965 | 0.72 | MAPT (0.38) | HPGDCYP1A2CYP3A4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |