Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637048 | 0.83 | NPSR1 (0.41) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL1450757 | 0.77 | NPSR1 (0.45) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL860103 | 0.74 | NPSR1 (0.46) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL23538248 | 0.74 | NPSR1 (0.46) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL12233262 | 0.74 | NPSR1 (0.46) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL6338510 | 0.73 | NPSR1 (0.45) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL9627220 | 0.73 | NPSR1 (0.45) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL2594859 | 0.73 | NPSR1 (0.45) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL3709288 | 0.73 | NPSR1 (0.45) | NPSR1KDM4EMAPK8MAPK9MAPK10 | |
| SCHEMBL23413538 | 0.73 | NPSR1 (0.45) | NPSR1KDM4EMAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108383858-A | Treat the derivative of the imidazo thiadiazoles and Imidazopyrazines of platelet aggregation | 百时美施贵宝公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-104583218-B | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation | 百时美施贵宝公司 | 2018-04-24 | — | — | CN | disclosed |