SCHEMBL28217741

SCHEMBL28217741

CC(C)(C)NCC1CN(C(=O)c2cscc2Nc2ccc(I)cc2F)C1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 20/20 0.49
MAP2K2 P36507 15/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29413367 0.83 MAP2K1 (0.66) MAP2K1MAP2K2
SCHEMBL188813 0.83 MAP2K1 (0.66) MAP2K1MAP2K2
SCHEMBL1488332 0.82 MAP2K1 (0.71) MAP2K1MAP2K2
SCHEMBL29413463 0.82 MAP2K1 (0.71) MAP2K1MAP2K2
SCHEMBL189133 0.82 MAP2K1 (0.61) MAP2K1MAP2K2
SCHEMBL29413483 0.82 MAP2K1 (0.61) MAP2K1MAP2K2
SCHEMBL1488384 0.75 MAP2K1 (0.68) MAP2K1MAP2K2
SCHEMBL29413594 0.75 MAP2K1 (0.68) MAP2K1MAP2K2
SCHEMBL8243644 0.75 MAP2K1 (0.58) MAP2K1MAP2K2
SCHEMBL30220913 0.74 MAP2K1 (0.70) MAP2K1MAP2K2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104892582-B Azetidine as the mek inhibitor for treating proliferative disease 埃克塞利希斯股份有限公司 2019-09-27 CN disclosed
CN-103524392-B As for treating the azetidine of the MEK inhibitor of proliferative disease 埃克塞利希斯股份有限公司 2018-06-01 CN disclosed