SCHEMBL28218784

SCHEMBL28218784

CC(C)n1cnc(C(=O)OBr)c1

nearest known ligand 0.44

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
KDM5A P29375 17/20 0.44
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1829517 0.84 MEN1 (0.46) KDM5ACDK5CDK5R1
SCHEMBL12458255 0.80 NOTUM (0.49) KDM5A
SCHEMBL30268950 0.80 KDM5A (0.49) KDM5A
SCHEMBL25588351 0.79 KDM5A (0.41) KDM5A
SCHEMBL710186 0.78 KDM5A (0.48) KDM5A
SCHEMBL15329155 0.78 KDM5A (0.48) KDM5A
SCHEMBL24268206 0.77 ADA (0.53) KDM5A
Hydrochloric Acid SCHEMBL29910419 0.77 KDM5A (0.47) KDM5A
SCHEMBL27894407 0.77 KDM5A (0.47) KDM5A
SCHEMBL12277334 0.74 KDM5A (0.47) KDM5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105209467-B Imidazopyrrolidinone derivatives and their use in the treatment of disease 诺华股份有限公司 2018-06-08 CN disclosed