Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.77 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.77 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.67 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821291 | 0.92 | PDE4B (0.74) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2821780 | 0.91 | PDE4B (0.80) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2822425 | 0.90 | PDE4B (0.75) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2826487 | 0.89 | PDE4B (0.81) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2821614 | 0.88 | PDE4B (0.88) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2826200 | 0.87 | PDE4B (1.00) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2823190 | 0.86 | PDE4B (0.74) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2825733 | 0.85 | PDE4B (0.90) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2822457 | 0.85 | PDE4B (0.68) | PDE4BADORA1ADORA2AADORA2B | |
| SCHEMBL2823302 | 0.85 | PDE4B (0.80) | PDE4BADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | claimed |
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |