Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28154587 | 0.88 | HRH3 (0.37) | HRH3 | |
| SCHEMBL28218743 | 0.86 | HRH3 (0.32) | HRH3 | |
| SCHEMBL12635250 | 0.83 | HRH3 (0.38) | HRH3PDCD1CD274HDAC4 | |
| SCHEMBL28168235 | 0.78 | KDM4E (0.32) | — | |
| SCHEMBL13275116 | 0.77 | HSD17B10 (0.41) | HRH3PDCD1CD274HDAC4 | |
| SCHEMBL1007612 | 0.75 | KDM4E (0.44) | HRH3 | |
| SCHEMBL19617492 | 0.75 | HRH3 (0.38) | HRH3PDCD1CD274HDAC4 | |
| SCHEMBL12311368 | 0.75 | HRH3 (0.36) | HRH3PDCD1CD274HDAC4 | |
| SCHEMBL7859519 | 0.75 | — | — | |
| SCHEMBL21163856 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104650068-B | Dihydropyrimidines and its application in drug | 广东东阳光药业有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-104487441-B | It is useful for the reversible covalent pyrrolopyrimidine or pyrazolopyrimidine for the treatment of cancer and autoimmune disease | 普林斯匹亚生物制药公司 | 2018-06-01 | — | — | CN | disclosed |