Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23765926 | 0.90 | KCNA3 (0.49) | KCNA3CTSKSLC18A3DRD2CCR5 | |
| SCHEMBL12788369 | 0.86 | KCNA3 (0.55) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL3115202 | 0.86 | KCNA3 (0.55) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL13612905 | 0.84 | KCNA3 (0.53) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL26665267 | 0.83 | KCNA3 (0.57) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL12971748 | 0.83 | KCNA3 (0.57) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL619386 | 0.83 | KCNA3 (0.57) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL26813364 | 0.83 | KCNA3 (0.52) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL28665607 | 0.83 | KCNA3 (0.55) | KCNA3CTSKDRD2CCR5DRD3 | |
| SCHEMBL26813360 | 0.83 | KCNA3 (0.52) | KCNA3CTSKDRD2CCR5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |