Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.46 |
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461662 | 0.67 | SMN1; SMN2 (0.66) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL34059 | 0.67 | SMN1; SMN2 (0.72) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL28209542 | 0.67 | TP53 (0.53) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL27048496 | 0.67 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| Hydrochloric Acid SCHEMBL5228080 | 0.65 | SMN1; SMN2 (0.70) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL8958738 | 0.65 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL1143440 | 0.64 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL21622380 | 0.64 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL13858697 | 0.64 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL11836620 | 0.64 | SMN1; SMN2 (0.62) | NPC1RAB9ASMN1; SMN2MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108329246-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compound as TRKA kinase inhibitors | 阵列生物制药公司 | 2018-07-27 | — | — | CN | disclosed |