Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27772138 | 0.93 | TSHR (0.43) | TSHRALDH1A1POLBPSEN1PSEN2 | |
| Cyclobutanol SCHEMBL29159670 | 0.88 | TSHR (0.47) | TSHRHPGDALDH1A1GLAPOLB | |
| SCHEMBL27938367 | 0.88 | TSHR (0.43) | TSHRHPGDALDH1A1GLAPOLB | |
| SCHEMBL27873296 | 0.87 | TSHR (0.46) | TSHRALDH1A1MAOAMAOB | |
| Benzene SCHEMBL25178056 | 0.84 | TSHR (0.52) | TSHRALDH1A1MAOAMAOB | |
| SCHEMBL901056 | 0.84 | TSHR (0.52) | TSHRALDH1A1MAOAMAOB | |
| SCHEMBL503 | 0.84 | TSHR (0.52) | TSHRALDH1A1MAOAMAOB | |
| SCHEMBL27486124 | 0.84 | IDO1 (0.42) | TSHRSMN1; SMN2MAOAMAOBOPRM1 | |
| Propane SCHEMBL27744553 | 0.83 | TSHR (0.46) | TSHRALDH1A1MAOAMAOB | |
| Methylamine SCHEMBL27600232 | 0.83 | IDO1 (0.48) | TSHRALDH1A1SMN1; SMN2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108513574-A | N-sulfonylated pyrazolo [3,4-b ] pyridine-6-carboxamides and methods of use | 艾伯维公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-108431002-A | Substituted pyrazolo [3, 4-b ] pyridine-6-carboxylic acids and uses thereof | 艾伯维公司 | 2018-08-21 | — | — | CN | disclosed |