Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.90 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786817 | 0.95 | MKNK1 (1.00) | MKNK1MKNK2BRAFEIF2AK3CYP1A2 | |
| SCHEMBL18786614 | 0.79 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18786719 | 0.75 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18786784 | 0.72 | MKNK1 (0.69) | MKNK1MKNK2MPLEIF4E | |
| SCHEMBL18786803 | 0.70 | MKNK1 (0.58) | MKNK1MKNK2EGFRERBB2MPL | |
| SCHEMBL18786706 | 0.70 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL14527953 | 0.70 | MKNK1 (0.58) | MKNK1BRAFEIF2AK3CHEK1EGFR | |
| SCHEMBL18786911 | 0.69 | MKNK1 (0.57) | MKNK1MKNK2CHEK1FLT3EGFR | |
| SCHEMBL18815026 | 0.69 | MKNK1 (0.56) | MKNK1MKNK2EGFRERBB2MPL | |
| SCHEMBL18786718 | 0.69 | MKNK1 (0.59) | MKNK1MKNK2MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |