⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165606 | 1.00 | — | — | |
| SCHEMBL28956066 | 0.88 | MAPK1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL5368702 | 0.85 | MAPK1 (0.31) | — | |
| SCHEMBL21395052 | 0.83 | — | — | |
| SCHEMBL27371167 | 0.75 | — | — | |
| SCHEMBL27379022 | 0.75 | — | — | |
| SCHEMBL2859149 | 0.72 | — | — | |
| SCHEMBL23747471 | 0.69 | — | — | |
| SCHEMBL28149301 | 0.69 | — | — | |
| SCHEMBL1644988 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937688-B1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |
| US-7507729-B2 | for the treatment of cognitive disorders, anxiety, schizophrenia, and Alzheimer's disease; ligands; GABA A alpha 5 receptor inhibitors; 3-bromo-10-chloro-6-(2-oxo-pyrrolidin-1-ylmethyl)-9H-imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine | HOFFMANN-LA ROCHE INC. (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082890-A1 | Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT | 2007-04-12 | — | — | US | disclosed |
| US-20040192697-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-09-30 | — | — | US | disclosed |
| WO-2004060893-A1 | PYRROLOPYRIDINE POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20040122218-A1 | Pyrrolopyridine potassium channel openers | ABBOTT LABORATORIES | 2004-06-24 | — | — | US | disclosed |