Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767396 | 0.87 | TSHR (0.72) | TSHRALDH1A1PARP1MAPTRAB9A | |
| SCHEMBL11293963 | 0.83 | MAPT (0.60) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL16701399 | 0.80 | TSHR (0.53) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL9245340 | 0.79 | TSHR (0.66) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL7820406 | 0.78 | HSD17B10 (0.57) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL29987983 | 0.78 | HSD17B10 (0.57) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL31547637 | 0.78 | BRD4 (0.58) | ERN1BRD4BRD9 | |
| SCHEMBL11695650 | 0.77 | TDP1 (0.52) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL10711975 | 0.77 | TDP1 (0.61) | TSHRALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL1086346 | 0.77 | TSHR (0.72) | TSHRALDH1A1PARP1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108690043-B | Quinoline derivatives and its preparation method and application | 东莞东阳光科研发有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-108690043-A | Quinoline derivatives and its preparation method and application | 东莞东阳光科研发有限公司 | 2018-10-23 | — | — | CN | disclosed |