Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Saccharin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 0.73 |
| ▸ | CA9 | Q16790 | 8/20 | 0.73 |
| ▸ | CA2 | P00918 | 7/20 | 0.73 |
| ▸ | CA1 | P00915 | 4/20 | 0.73 |
| ▸ | CA7 | P43166 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | USP2 | O75604 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | BCHE | P06276 | 1/20 | 0.73 |
| ▸ | CA4 | P22748 | 1/20 | 0.73 |
| ▸ | CA6 | P23280 | 1/20 | 0.73 |
| ▸ | CA5A | P35218 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.73 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.73 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saccharin SCHEMBL27518097 | 1.00 | CA12 (0.73) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27832154 | 0.97 | CA12 (0.73) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27496305 | 0.91 | CA12 (0.65) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL28045129 | 0.89 | CA12 (0.92) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL29270979 | 0.89 | CA12 (0.67) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL28742559 | 0.88 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL28334570 | 0.88 | CA12 (0.88) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL11399526 | 0.88 | CA12 (0.96) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10899217 | 0.88 | CA12 (0.96) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL9463482 | 0.88 | CA12 (0.96) | CA12CA9CA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108614053-A | The quick detection of preservative and sweetener in butter or cream | 内蒙古蒙牛乳业（集团）股份有限公司 | 2018-10-02 | — | — | CN | disclosed |