Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ascorbic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.83 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.52 |
| ▸ | TST | Q16762 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 2/20 | 0.43 |
| ▸ | MANBA | O00462 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.31 |
| ▸ | ACP1 | P24666 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ascorbic Acid SCHEMBL31356983 | 1.00 | MAPT (0.83) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL4087692 | 1.00 | MAPT (0.83) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL15226289 | 0.95 | MAPT (0.86) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL10642367 | 0.93 | MAPT (0.83) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL29992966 | 0.93 | MAPT (0.89) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL4146647 | 0.93 | MAPT (0.96) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL22589022 | 0.93 | MAPT (0.96) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL5432988 | 0.92 | MAPT (0.86) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL5879339 | 0.91 | MAPT (0.93) | MAPTLMNAL3MBTL1RECQLTDP1 | |
| Ascorbic Acid SCHEMBL2096728 | 0.91 | MAPT (0.93) | MAPTLMNAL3MBTL1RECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105832667-B | A kind of long chain fat emulsion injection and preparation method thereof containing olive oil | 济南康和医药科技有限公司 | 2018-11-30 | — | — | CN | disclosed |