Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.86 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.86 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.81 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824908 | 0.95 | PDE4B (0.82) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2823615 | 0.93 | PDE4B (1.00) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2829445 | 0.92 | PDE4B (0.90) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2825047 | 0.91 | PDE4B (1.00) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2823231 | 0.91 | PDE4B (0.90) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2821233 | 0.90 | PDE4B (0.99) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2823776 | 0.90 | PDE4B (0.94) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2825603 | 0.90 | PDE4B (1.00) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2822880 | 0.89 | PDE4B (0.93) | PDE4BADORA1ADORA2BADORA2A | |
| SCHEMBL2823617 | 0.89 | PDE4B (1.00) | PDE4BADORA1ADORA2BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | claimed |
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |