Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CSK | P41240 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20558357 | 0.89 | PARP10 (0.55) | PARP10CTNNB1TNKSPARP15PARP14 | |
| SCHEMBL28949675 | 0.85 | HPGD (0.39) | PARP10NPC1HPGDCRHBPRAB9A | |
| SCHEMBL28949678 | 0.81 | RHEB (0.40) | NPC1HPGDCRHBPRAB9ACRHR2 | |
| SCHEMBL2380185 | 0.77 | AKR1C3 (0.46) | PARP10NPC1HPGDCRHBPRAB9A | |
| SCHEMBL14992586 | 0.76 | HPGD (0.47) | PARP10NPC1HPGDCRHBPRAB9A | |
| SCHEMBL18956930 | 0.76 | MEN1 (0.44) | NPC1RAB9ARHEB | |
| SCHEMBL27898917 | 0.73 | NPC1 (0.45) | NPC1HPGDCRHBPRAB9ACRHR2 | |
| SCHEMBL28260959 | 0.73 | PARP10 (0.56) | PARP10LCKSRCCSKCTNNB1 | |
| SCHEMBL27486214 | 0.73 | PARP10 (0.61) | PARP10CTNNB1TNKSPARP15PARP14 | |
| SCHEMBL23104947 | 0.73 | MCL1 (0.42) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071563-A | Inhibitors of bruton's tyrosine kinase and methods of use thereof | 詹森药业有限公司 | 2018-12-21 | — | — | CN | disclosed |