Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789110 | 0.85 | KDM4E (0.51) | KDM4EGPR183KMT2AMEN1ALDH1A1 | |
| SCHEMBL10263815 | 0.83 | PIK3CD (0.52) | KDM4EGPR183KMT2AMEN1ALDH1A1 | |
| SCHEMBL13505883 | 0.83 | KDM4E (0.40) | KDM4EGPR183KMT2AALDH1A1HRH3 | |
| SCHEMBL20621109 | 0.82 | KDM4E (0.56) | KDM4EGPR183KMT2AMEN1ALDH1A1 | |
| SCHEMBL21152530 | 0.82 | KDM4E (0.49) | KDM4EGPR183KMT2AMEN1 | |
| SCHEMBL19087078 | 0.82 | KDM4E (0.49) | KDM4EGPR183KMT2AMEN1ALDH1A1 | |
| SCHEMBL29162704 | 0.82 | KDM4E (0.39) | KDM4EGPR183KMT2AALDH1A1HRH3 | |
| SCHEMBL27571754 | 0.81 | KDM4E (0.53) | KDM4EKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL31207187 | 0.80 | KDM4E (0.55) | KDM4EGPR183ALDH1A1TP53HRH3 | |
| SCHEMBL5208600 | 0.79 | HRH3 (0.41) | KDM4EGPR183KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109134431-B | Aminoimidazole-coupled pyridone derivatives as cystic fibrosis transmembrane conductance regulator inhibitors | 成都理工大学 | 2021-06-04 | — | — | CN | disclosed |
| CN-109134431-A | Aminooimidazole as cystic fibrosis transmembrane conductance regulator inhibitor is coupled Pyridione derivatives | 成都理工大学 | 2019-01-04 | — | — | CN | disclosed |