Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805677 | 1.00 | JAK2 (0.47) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL3805674 | 1.00 | JAK2 (0.47) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2849228 | 0.93 | JAK2 (0.49) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2849224 | 0.93 | JAK2 (0.49) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2845920 | 0.89 | HTR2A (0.40) | CCR5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2845923 | 0.89 | HTR2A (0.40) | CCR5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2850358 | 0.88 | JAK2 (0.52) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2850359 | 0.88 | JAK2 (0.52) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2844701 | 0.87 | JAK2 (0.48) | JAK2JAK1HSD11B1GPR119USP30 | |
| SCHEMBL2844705 | 0.87 | JAK2 (0.48) | JAK2JAK1HSD11B1GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2226322-B1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| EP-2226322-A1 | IMIDAZOLE CARBONYL COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2010-09-08 | — | — | EP | disclosed |