Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mizolastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 19/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.95 |
| ▸ | HTR2B | P41595 | 1/20 | 0.95 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.95 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 17/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mizolastine SCHEMBL29369194 | 0.97 | HRH1 (1.00) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| Mizolastine SCHEMBL5061 | 0.97 | HRH1 (1.00) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| Mizolastine SCHEMBL29256081 | 0.97 | HRH1 (0.98) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| Mizolastine SCHEMBL4443891 | 0.83 | HRH1 (0.73) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL18388464 | 0.82 | HRH1 (0.78) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL12045361 | 0.82 | HRH1 (0.68) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| Mizolastine SCHEMBL6273027 | 0.82 | HRH1 (0.84) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL12045419 | 0.82 | HRH1 (0.67) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL18597171 | 0.81 | HRH1 (0.74) | HRH1KCNH2CHRM1ADRA2AHTR2B | |
| SCHEMBL12668369 | 0.81 | HRH1 (0.69) | HRH1KCNH2CHRM1ADRA2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109010253-A | A kind of preparation method of Mizolastine sustained release preparation | 刘丽 | 2018-12-18 | — | — | CN | disclosed |