SCHEMBL28268741

SCHEMBL28268741

N[C@@H]1C=Cc2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.46
HTR6 P50406 1/20 0.44
KDM4E B2RXH2 3/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
TP53 P04637 2/20 0.34
CYP3A4 P08684 2/20 0.34
HSD17B10 Q99714 2/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPT P10636 1/20 0.34
PKM P14618 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
ALOX12 P18054 1/20 0.34
SIGMAR1 Q99720 6/20 0.33
CYP2D6 P10635 2/20 0.33
BRD4 O60885 1/20 0.33
CCL2 P13500 1/20 0.33
LMNA P02545 1/20 0.33
CHRM2 P08172 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2404712 1.00 HTR2A (0.46) HTR2AHTR6KDM4EMEN1KMT2A
SCHEMBL29415503 1.00 HTR2A (0.46) HTR2AHTR6KDM4EMEN1KMT2A
SCHEMBL29732957 1.00 HTR2A (0.46) HTR2AHTR6KDM4EMEN1KMT2A
SCHEMBL22321060 1.00 HTR2A (0.46) HTR2AHTR6KDM4EMEN1KMT2A
SCHEMBL28838886 0.93 HTR2A (0.42) HTR2AHTR6KDM4EMEN1KMT2A
Formic Acid SCHEMBL14919377 0.88 HTR2A (0.38) HTR2AHTR6KDM4EMEN1KMT2A
Phosphoric Acid SCHEMBL30747062 0.88 HTR2A (0.38) HTR2AHTR6KDM4EMEN1KMT2A
Acetic Acid SCHEMBL31548595 0.86 MEN1 (0.37) HTR2AHTR6MEN1KMT2AALDH1A1
Succinic Acid SCHEMBL31548608 0.83 NR4A2 (0.40) HTR2AHTR6ALDH1A1CYP2D6LMNA
Trifluoroacetic Acid SCHEMBL4280931 0.82 CES1 (0.36) HTR2AHTR6MEN1KMT2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119707698-A Process method for synthesizing (S) - (+) -1-aminoindene 大连双硼医药化工有限公司 2025-03-28 CN claimed
CN-109180499-A The preparation method of rasagiline mesilate and its intermediate 上海博志研新药物技术有限公司 2019-01-11 CN claimed
CN-122079792-A Synthesis method of chiral indene amine 2026-05-26 CN disclosed
CN-122079791-A Racemization method of chiral indene amine 2026-05-26 CN disclosed
CN-119798092-A Imine intermediate of indenofloxacin, cis-indene intermediate and preparation method thereof 宁夏格瑞精细化工有限公司 2025-04-11 CN disclosed
CN-119707698-A Process method for synthesizing (S) - (+) -1-aminoindene 大连双硼医药化工有限公司 2025-03-28 CN disclosed
CN-119661374-A Method for preparing (1R, 2S) -2, 6-dimethyl-1-indene amine by using chiral amino acid resolving agent 中国科学院大连化学物理研究所 2025-03-21 CN disclosed
CN-119462395-A Synthesis method of chiral indene amine 中国科学院大连化学物理研究所 2025-02-18 CN disclosed
CN-115947675-B Rasagiline intermediate and preparation method and application thereof 博济医药科技股份有限公司 2024-05-31 CN disclosed
CN-117288864-A Chiral resolution method of DL-lactic acid and application of chiral resolution method in detection method of DL-lactic acid in human sweat 延边大学 2023-12-26 CN disclosed
CN-115947675-A Rasagiline intermediate and preparation method and application thereof 博济医药科技股份有限公司 2023-04-11 CN disclosed
CN-115916176-A Inhibitors of alpha 2 beta 1 integrin and methods of use thereof 加利福尼亚大学董事会 2023-04-04 CN disclosed
CN-109180499-A The preparation method of rasagiline mesilate and its intermediate 上海博志研新药物技术有限公司 2019-01-11 CN disclosed